Monday, August 9, 2010
Lipoic Acid Could Reduce Atherosclerosis
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Science News
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Lipoic Acid Could Reduce Atherosclerosis, Weight Gain
ScienceDaily (Jan. 17, 2008) — A new study done with mice has discovered that supplements of lipoic acid can inhibit formation of arterial lesions, lower triglycerides, and reduce blood vessel inflammation and weight gain -- all key issues for addressing cardiovascular disease.
See Also:
Health & Medicine
* Diet and Weight Loss
* Heart Disease
* Stroke Prevention
* Cholesterol
* Fitness
* Obesity
Reference
* Low density lipoprotein
* Hypercholesterolemia
* Polyphenol antioxidant
* High density lipoprotein
Although the results cannot be directly extrapolated beyond the laboratory, researchers report that "they strongly suggest that lipoic acid supplementation may be useful as an inexpensive but effective intervention strategy . . . reducing known risk factors for the development of atherosclerosis and other inflammatory vascular diseases in humans."
The findings were made by scientists from the Linus Pauling Institute and College of Veterinary Medicine at Oregon State University, and the Department of Medicine at the University of Washington.
Heart disease is the leading cause of death in the United States.
The study found that lipoic acid supplements reduced atherosclerotic lesion formation in two types of mice that are widely used to study cardiovascular disease, by 55 percent and 40 percent, respectively. The supplements were also associated with almost 40 percent less body weight gain, and lower levels of triglycerides in very low-density lipoproteins.
As a result, the authors concluded that "lipoic acid may be a useful adjunct in the prevention and treatment of atherosclerotic vascular diseases."
"We are excited about these results, particularly since the supplements of lipoic acid appear to provide several different mechanisms to improve cardiovascular health," said Balz Frei, professor and director of the Linus Pauling Institute. "They are helping in a fundamental way to reset and normalize metabolic processes, in ways that could help address one of the most significant health problems in the Western world.
"These findings also reinforce the need for more comprehensive human studies," Frei said. "That will be the next step in our research, in double-blind, randomized, clinical studies during the next five years with Oregon Health and Science University."
Alpha lipoic acid is a naturally occurring nutrient found at low levels in green leafy vegetables, potatoes and meats, especially organ meats such as kidney, heart or liver. The amounts used in this research would not be obtainable by any normal diet, researchers said, and for human consumption might equate to supplements of about 2,000 milligrams per day. Even at low, normal, dietary levels, the compound can play a key role in energy metabolism.
Atherosclerosis, or what used to be called "hardening of the arteries," is a long-term process that is now seen as a chronic inflammatory disease, which begins when certain types of white blood cells called monocytes bind to "adhesion molecules" on the walls of arteries. This in turn allows the monocytes to enter the arterial wall, there they become inflammatory macrophages that, in the presence of low density lipoprotein, or LDL, can transform into lipid-laden foam cells -- ultimately, an arterial fat deposit.
This chronic process often begins during adolescence, can continue for a lifetime, and has been linked to obesity, poor diet, lack of exercise, diabetes, high blood pressure, genetic predisposition and other causes. The fatty deposits in arteries can ultimately trigger a heart attack or stroke.
Researchers now believe that high levels of alpha lipoic acid can be particularly useful in preventing this process, by inhibiting the formation of the adhesion molecules. It can also lower triglycerides, another important risk factor for cardiovascular disease. It may also function as an antioxidant, and helps to normalize insulin signaling and glucose metabolism.
"From what we understand, this supplement would be most valuable as a preventive mechanism before people have advanced cardiovascular disease," Frei said. "However, it may help retard the process at any stage, and may also be of value in treating diabetic complications."
Also of considerable interest, Frei said, is the apparent role of lipoic acid supplementation in reducing weight gain. It appears to have this effect both through appetite suppression, an enhanced metabolic rate, and -- at least in laboratory animals -- has been shown to stimulate higher levels of physical activity, which again would increase caloric expenditure and further reduce weight.
Mice given lipoic acid supplements simply chose to eat less than a control group that did not receive supplements, suggesting a reduced appetite. In another test, mice that received supplements gained less weight than other mice in a control group that were given identical amounts to eat, suggesting a higher metabolic rate and enhanced activity levels.
Weight gain and obesity is a major risk factor for atherosclerosis and heart disease, and lower weight and abdominal fat may be one of the mechanisms by which lipoic acid has beneficial effects, Frei said. The study concluded that "lipoic acid supplementation may be a promising approach to prevent weight gain and to lower cardiovascular disease risk in humans."
Although some of the most compelling research with lipoic acid research has been done in mouse models, scientists say, there should be a reasonable extrapolation to humans, because the lipoprotein profile is similar, as well as the composition of the atherosclerotic lesions. These mouse models are routinely used in studies of human atherosclerosis.
The full study was recently published in Circulation, a journal of the American Heart Association.
This research was supported by the National Institutes of Health and the National Center for Complementary and Alternative Medicine.
Science News
Share Blog Cite
Print Email Bookmark
Lipoic Acid Could Reduce Atherosclerosis, Weight Gain
ScienceDaily (Jan. 17, 2008) — A new study done with mice has discovered that supplements of lipoic acid can inhibit formation of arterial lesions, lower triglycerides, and reduce blood vessel inflammation and weight gain -- all key issues for addressing cardiovascular disease.
See Also:
Health & Medicine
* Diet and Weight Loss
* Heart Disease
* Stroke Prevention
* Cholesterol
* Fitness
* Obesity
Reference
* Low density lipoprotein
* Hypercholesterolemia
* Polyphenol antioxidant
* High density lipoprotein
Although the results cannot be directly extrapolated beyond the laboratory, researchers report that "they strongly suggest that lipoic acid supplementation may be useful as an inexpensive but effective intervention strategy . . . reducing known risk factors for the development of atherosclerosis and other inflammatory vascular diseases in humans."
The findings were made by scientists from the Linus Pauling Institute and College of Veterinary Medicine at Oregon State University, and the Department of Medicine at the University of Washington.
Heart disease is the leading cause of death in the United States.
The study found that lipoic acid supplements reduced atherosclerotic lesion formation in two types of mice that are widely used to study cardiovascular disease, by 55 percent and 40 percent, respectively. The supplements were also associated with almost 40 percent less body weight gain, and lower levels of triglycerides in very low-density lipoproteins.
As a result, the authors concluded that "lipoic acid may be a useful adjunct in the prevention and treatment of atherosclerotic vascular diseases."
"We are excited about these results, particularly since the supplements of lipoic acid appear to provide several different mechanisms to improve cardiovascular health," said Balz Frei, professor and director of the Linus Pauling Institute. "They are helping in a fundamental way to reset and normalize metabolic processes, in ways that could help address one of the most significant health problems in the Western world.
"These findings also reinforce the need for more comprehensive human studies," Frei said. "That will be the next step in our research, in double-blind, randomized, clinical studies during the next five years with Oregon Health and Science University."
Alpha lipoic acid is a naturally occurring nutrient found at low levels in green leafy vegetables, potatoes and meats, especially organ meats such as kidney, heart or liver. The amounts used in this research would not be obtainable by any normal diet, researchers said, and for human consumption might equate to supplements of about 2,000 milligrams per day. Even at low, normal, dietary levels, the compound can play a key role in energy metabolism.
Atherosclerosis, or what used to be called "hardening of the arteries," is a long-term process that is now seen as a chronic inflammatory disease, which begins when certain types of white blood cells called monocytes bind to "adhesion molecules" on the walls of arteries. This in turn allows the monocytes to enter the arterial wall, there they become inflammatory macrophages that, in the presence of low density lipoprotein, or LDL, can transform into lipid-laden foam cells -- ultimately, an arterial fat deposit.
This chronic process often begins during adolescence, can continue for a lifetime, and has been linked to obesity, poor diet, lack of exercise, diabetes, high blood pressure, genetic predisposition and other causes. The fatty deposits in arteries can ultimately trigger a heart attack or stroke.
Researchers now believe that high levels of alpha lipoic acid can be particularly useful in preventing this process, by inhibiting the formation of the adhesion molecules. It can also lower triglycerides, another important risk factor for cardiovascular disease. It may also function as an antioxidant, and helps to normalize insulin signaling and glucose metabolism.
"From what we understand, this supplement would be most valuable as a preventive mechanism before people have advanced cardiovascular disease," Frei said. "However, it may help retard the process at any stage, and may also be of value in treating diabetic complications."
Also of considerable interest, Frei said, is the apparent role of lipoic acid supplementation in reducing weight gain. It appears to have this effect both through appetite suppression, an enhanced metabolic rate, and -- at least in laboratory animals -- has been shown to stimulate higher levels of physical activity, which again would increase caloric expenditure and further reduce weight.
Mice given lipoic acid supplements simply chose to eat less than a control group that did not receive supplements, suggesting a reduced appetite. In another test, mice that received supplements gained less weight than other mice in a control group that were given identical amounts to eat, suggesting a higher metabolic rate and enhanced activity levels.
Weight gain and obesity is a major risk factor for atherosclerosis and heart disease, and lower weight and abdominal fat may be one of the mechanisms by which lipoic acid has beneficial effects, Frei said. The study concluded that "lipoic acid supplementation may be a promising approach to prevent weight gain and to lower cardiovascular disease risk in humans."
Although some of the most compelling research with lipoic acid research has been done in mouse models, scientists say, there should be a reasonable extrapolation to humans, because the lipoprotein profile is similar, as well as the composition of the atherosclerotic lesions. These mouse models are routinely used in studies of human atherosclerosis.
The full study was recently published in Circulation, a journal of the American Heart Association.
This research was supported by the National Institutes of Health and the National Center for Complementary and Alternative Medicine.
Quercetin
Quercetin is a phytochemical that is part of the coloring found in the skins of apples and red onions. It has been isolated and is sold as a dietary supplement.
In the Body:
Quercetin is a powerful antioxidant. It is also a natural anti-histamine, and anti-inflammatory. Research shows that quercetin may help to prevent cancer, especially prostate cancer.
Why Use It:
Quercetin's antihistamine action may help to relieve allergic symptoms and asthma symptoms. The anti-inflammatory properties may help to reduce pain from disorders such as arthritis. Men who are concerned about prostate problems would also benefit from quercetin. Quercetin may also help reduce symptoms like fatigue, depression and anxiety.
Where To Find Quercetin:
To get more quercetin, you can increase your intake of apples and red onions, which will improve your diet. If you want more quercetin, you can take a dietary supplement. FRS Healthy Energy (buy direct) offers energy drinks with quercetin, green tea extract and vitamins.
In the Body:
Quercetin is a powerful antioxidant. It is also a natural anti-histamine, and anti-inflammatory. Research shows that quercetin may help to prevent cancer, especially prostate cancer.
Why Use It:
Quercetin's antihistamine action may help to relieve allergic symptoms and asthma symptoms. The anti-inflammatory properties may help to reduce pain from disorders such as arthritis. Men who are concerned about prostate problems would also benefit from quercetin. Quercetin may also help reduce symptoms like fatigue, depression and anxiety.
Where To Find Quercetin:
To get more quercetin, you can increase your intake of apples and red onions, which will improve your diet. If you want more quercetin, you can take a dietary supplement. FRS Healthy Energy (buy direct) offers energy drinks with quercetin, green tea extract and vitamins.
Monday, August 2, 2010
Asparagus -- Who Knew?
My Mom had been taking the full-stalk canned style
asparagus that she pureed and she took 4 tablespoons in
the morning and 4 tablespoons later in the day. She did
this for over a month. She is on chemo pills for Stage 3
lung cancer in the pleural area and her cancer count went
from 386 down to 125 as of this past week.
Her oncologist said she does not need to see him for 3 months.
THE ARTICLE:
Several years ago, I had a man seeking asparagus for a
friend who had cancer. He gave me a photocopied copy of
an article, entitled, Asparagus for cancer 'printed in
Cancer News Journal, December 1979. I will share it
here, just as it was shared with me: I am a biochemist,
and have specialized in the relation of diet to health
for over 50 years. Several years ago, I learned of the
discovery of Richard R. Vensal, D.D.S. that asparagus
might cure cancer. Since then, I have worked with him on
his project. We have accumulated a number of favorable
case histories. Here are a few examples:
Case No. 1,
A man with an almost hopeless case of Hodgkin's disease
(cancer of the lymph glands) who was completely incapacitated.
Within 1 year of starting asparagus therapy, his doctors were
unable to detect any signs of cancer, and he was back on a
schedule of strenuous exercise.
Case No. 2,
A successful businessman 68 years old who suffered from cancer
of the bladder for 16 years. After years of medical treatments,
including radiation without improvement, he went on asparagus.
Within 3 months, examinations revealed that his bladder
tumor had disappeared and that his kidneys were normal.
Case No. 3,
A man who had lung cancer. On March 5th 1971, he was put
on the operating table where they found lung cancer so
widely spread that it was inoperable. The surgeon sewed
him up and declared his case hopeless. On April 5th he
heard about the Asparagus therapy and immediately started
taking it By August, x-ray revealed that all signs of the cancer
had disappeared.. He is back at his regular business routine.
Case No. 4,
A woman who was troubled for a number of years with skin
cancer. She finally developed different skin cancers which were
diagnosed by the acting specialist as advanced. Within 3 months
after starting on asparagus, her skin specialist said that her skin
looked fine and no more skin lesions. This woman reported that
the asparagus therapy also cured her kidney disease, which started
in 1949. She had over 10 operations for kidney stones, and was
receiving government disability payments for an inoperable,
terminal, kidney condition. She attributes the cure of this kidney
trouble entirely to the asparagus.
I was not surprised at this result, as `The elements of
material medica', edited in 1854 by a Professor at the
University of Pennsylvania , stated that asparagus was
used as a popular remedy for kidney stones. He even
referred to experiments, in 1739, on the power of
asparagus in dissolving stones. Note the dates!
We would have other case histories but the medical
establishment has interfered with our obtaining some of
the records. I am therefore appealing to readers to
spread this good news and help us to gather a large
number of case histories that will overwhelm the medical
skeptics about this unbelievably simple and natural remedy.
For the treatment, asparagus should be cooked before
using, and therefore canned asparagus is just as good as
fresh. I have corresponded with the two leading canners
of asparagus, Giant and Stokely, and I am satisfied that
these brands contain no pesticides or preservatives.
Place the cooked asparagus in a blender and liquefy to
make a puree, and store in the refrigerator. Give the
patient 4 full tablespoons twice daily, morning and
evening. Patients usually show some improvement in from
2-4 weeks. It can be diluted with water and used as a
cold or hot drink. This suggested dosage is based on
present experience, but certainly larger amounts can do
no harm and may be needed in some cases. As a biochemist
I am convinced of the old saying that `what cures can
prevent.' Based on this theory, my wife and I have been
using asparagus puree as a beverage with our meals. We
take 2 tablespoons diluted in water to suit our taste
with breakfast and with dinner. I take mine hot and my
wife prefers hers cold. For years we have made it a
practice to have blood surveys taken as part of our
regular checkups. The last blood survey, taken by a
medical doctor who specializes in the nutritional
approach to health, showed substantial improvements in
all categories over the last one, and we can attribute
these improvements to nothing but the asparagus drink.
As a biochemist, I have made an extensive study of all
aspects of cancer, and all of the proposed cures. As a
result, I am convinced that asparagus fits in better
with the latest theories about cancer.
Asparagus contains a good supply of protein called
histones, which are believed to be active in controlling
cell growth.. For that reason, I believe asparagus can
be said to contain a substance that I call cell growth
normalizer. That accounts for its action on cancer and
in acting as a general body tonic. In any event,
regardless of theory, asparagus used as we suggest, is a
harmless substance. The FDA cannot prevent you from
using it and it may do you much good. It has been
reported by the US National Cancer Institute, that
asparagus is the highest tested food containing
glutathione, which is considered one of the body's most
potent anticarcinogens and antioxidants.
Please send this article to everyone in your Address Book.
The most unselfish act one can ever do is paying forward
all the kindness one has received, even to the most undeserved
person.
Histones
Histones are proteins around which DNA can wind. They play an important role in gene regulation in eukaryotic cells and in the Euryarchaea bacteria of the family Archaea. Histones are highly water soluble.
The six histone classes are H1, H2A, H2B, H3, H4, and Archaeal. All but the H1 and Archaeal classes create nucleosome core particles by wrapping DNA around their protein spools; the H1 then binds nucleosomes and entry and exit sites of the DNA. Histones and DNA assembled in this way are called chromatin.
Histones have several functions. They pack proteins so that they'll fit inside cell nuclei. Packed DNA are 50,000 times shorter than unpacked ones. They also perform a function in gene regulation; methylation causes tighter bindings to down-regulate or even inhibit gene transcription, while acetylation loosens bindings to help encourage transcription and translation. The other functions performed by histones are phosphorylation, ubiquitination, and ADP-ribosylation.
Histones were discovered in 1884 by Albrecht Kossel, though he dismissed them as of little importance. Only recently has the real function and value of the histone in protein regulation been understood.
Web Resources On Histones
The Nucleus
Acetylation of Histones and Transcription-Related Factors
Book Resources On Histones
Histones and Other Basic Nuclear Proteins by Lubomir S. Hnilica et al
The structure and biological function of histones by Lubomir S Hnilica
Contributed by Jaribu BoBo (Marcella Jennings)
asparagus that she pureed and she took 4 tablespoons in
the morning and 4 tablespoons later in the day. She did
this for over a month. She is on chemo pills for Stage 3
lung cancer in the pleural area and her cancer count went
from 386 down to 125 as of this past week.
Her oncologist said she does not need to see him for 3 months.
THE ARTICLE:
Several years ago, I had a man seeking asparagus for a
friend who had cancer. He gave me a photocopied copy of
an article, entitled, Asparagus for cancer 'printed in
Cancer News Journal, December 1979. I will share it
here, just as it was shared with me: I am a biochemist,
and have specialized in the relation of diet to health
for over 50 years. Several years ago, I learned of the
discovery of Richard R. Vensal, D.D.S. that asparagus
might cure cancer. Since then, I have worked with him on
his project. We have accumulated a number of favorable
case histories. Here are a few examples:
Case No. 1,
A man with an almost hopeless case of Hodgkin's disease
(cancer of the lymph glands) who was completely incapacitated.
Within 1 year of starting asparagus therapy, his doctors were
unable to detect any signs of cancer, and he was back on a
schedule of strenuous exercise.
Case No. 2,
A successful businessman 68 years old who suffered from cancer
of the bladder for 16 years. After years of medical treatments,
including radiation without improvement, he went on asparagus.
Within 3 months, examinations revealed that his bladder
tumor had disappeared and that his kidneys were normal.
Case No. 3,
A man who had lung cancer. On March 5th 1971, he was put
on the operating table where they found lung cancer so
widely spread that it was inoperable. The surgeon sewed
him up and declared his case hopeless. On April 5th he
heard about the Asparagus therapy and immediately started
taking it By August, x-ray revealed that all signs of the cancer
had disappeared.. He is back at his regular business routine.
Case No. 4,
A woman who was troubled for a number of years with skin
cancer. She finally developed different skin cancers which were
diagnosed by the acting specialist as advanced. Within 3 months
after starting on asparagus, her skin specialist said that her skin
looked fine and no more skin lesions. This woman reported that
the asparagus therapy also cured her kidney disease, which started
in 1949. She had over 10 operations for kidney stones, and was
receiving government disability payments for an inoperable,
terminal, kidney condition. She attributes the cure of this kidney
trouble entirely to the asparagus.
I was not surprised at this result, as `The elements of
material medica', edited in 1854 by a Professor at the
University of Pennsylvania , stated that asparagus was
used as a popular remedy for kidney stones. He even
referred to experiments, in 1739, on the power of
asparagus in dissolving stones. Note the dates!
We would have other case histories but the medical
establishment has interfered with our obtaining some of
the records. I am therefore appealing to readers to
spread this good news and help us to gather a large
number of case histories that will overwhelm the medical
skeptics about this unbelievably simple and natural remedy.
For the treatment, asparagus should be cooked before
using, and therefore canned asparagus is just as good as
fresh. I have corresponded with the two leading canners
of asparagus, Giant and Stokely, and I am satisfied that
these brands contain no pesticides or preservatives.
Place the cooked asparagus in a blender and liquefy to
make a puree, and store in the refrigerator. Give the
patient 4 full tablespoons twice daily, morning and
evening. Patients usually show some improvement in from
2-4 weeks. It can be diluted with water and used as a
cold or hot drink. This suggested dosage is based on
present experience, but certainly larger amounts can do
no harm and may be needed in some cases. As a biochemist
I am convinced of the old saying that `what cures can
prevent.' Based on this theory, my wife and I have been
using asparagus puree as a beverage with our meals. We
take 2 tablespoons diluted in water to suit our taste
with breakfast and with dinner. I take mine hot and my
wife prefers hers cold. For years we have made it a
practice to have blood surveys taken as part of our
regular checkups. The last blood survey, taken by a
medical doctor who specializes in the nutritional
approach to health, showed substantial improvements in
all categories over the last one, and we can attribute
these improvements to nothing but the asparagus drink.
As a biochemist, I have made an extensive study of all
aspects of cancer, and all of the proposed cures. As a
result, I am convinced that asparagus fits in better
with the latest theories about cancer.
Asparagus contains a good supply of protein called
histones, which are believed to be active in controlling
cell growth.. For that reason, I believe asparagus can
be said to contain a substance that I call cell growth
normalizer. That accounts for its action on cancer and
in acting as a general body tonic. In any event,
regardless of theory, asparagus used as we suggest, is a
harmless substance. The FDA cannot prevent you from
using it and it may do you much good. It has been
reported by the US National Cancer Institute, that
asparagus is the highest tested food containing
glutathione, which is considered one of the body's most
potent anticarcinogens and antioxidants.
Please send this article to everyone in your Address Book.
The most unselfish act one can ever do is paying forward
all the kindness one has received, even to the most undeserved
person.
Histones
Histones are proteins around which DNA can wind. They play an important role in gene regulation in eukaryotic cells and in the Euryarchaea bacteria of the family Archaea. Histones are highly water soluble.
The six histone classes are H1, H2A, H2B, H3, H4, and Archaeal. All but the H1 and Archaeal classes create nucleosome core particles by wrapping DNA around their protein spools; the H1 then binds nucleosomes and entry and exit sites of the DNA. Histones and DNA assembled in this way are called chromatin.
Histones have several functions. They pack proteins so that they'll fit inside cell nuclei. Packed DNA are 50,000 times shorter than unpacked ones. They also perform a function in gene regulation; methylation causes tighter bindings to down-regulate or even inhibit gene transcription, while acetylation loosens bindings to help encourage transcription and translation. The other functions performed by histones are phosphorylation, ubiquitination, and ADP-ribosylation.
Histones were discovered in 1884 by Albrecht Kossel, though he dismissed them as of little importance. Only recently has the real function and value of the histone in protein regulation been understood.
Web Resources On Histones
The Nucleus
Acetylation of Histones and Transcription-Related Factors
Book Resources On Histones
Histones and Other Basic Nuclear Proteins by Lubomir S. Hnilica et al
The structure and biological function of histones by Lubomir S Hnilica
Contributed by Jaribu BoBo (Marcella Jennings)
Sunday, August 1, 2010
Prostate Cancer Treatment
x-terpinene derived from
Chenopodium ambrosioides extract for treating uterine fibroids
Prostate Cancer Treatment
Learn More About Minimally Invasive Treatment For Faster Recovery Time.
www.RoboticOncology.com
A method of treating abnormal growths in a patient.
The growths include: cancers, tumors, fibroids, cysts, and cystadenomas.
Dry leaves and stalks of a Chenopodium ambrosioides plant into a dried tea.
Brew the dried tea in boiled water into a tea beverage.
Administer the tea beverage to the patient by having the patient drink the tea daily.
The method also reduces high PSA counts.
Chenopodium ambrosioides extract for treating uterine fibroids
Prostate Cancer Treatment
Learn More About Minimally Invasive Treatment For Faster Recovery Time.
www.RoboticOncology.com
A method of treating abnormal growths in a patient.
The growths include: cancers, tumors, fibroids, cysts, and cystadenomas.
Dry leaves and stalks of a Chenopodium ambrosioides plant into a dried tea.
Brew the dried tea in boiled water into a tea beverage.
Administer the tea beverage to the patient by having the patient drink the tea daily.
The method also reduces high PSA counts.
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